This study evaluates the economic contribution that Carilion Clinic makes to the state, its service region and individual service areas where it operates. The study has two components. The first part examines the economic contribution that results from clinic-related spending using IMPLAN input-output models. This contribution includes the economic activity stimulated by clinic payroll and procurement of supplies and services. The second part examines a broader set of economic and social benefits that result from the presence of the clinic, including workforce productivity improvement, education and research, and provision of regional amenities.